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In contrast to enzymes that digest biological material to release cells, SimpleFlow utilizes acoustic waves that dissociate more cells without bias.
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Figure 1. A single cell RNA-seq comparison of whole mouse brain dissociated with SimpleFlow and a commercially available enzyme kit.
Tissue was dissociated on the SimpleFlow using the mouse brain protocol which ran for 4 minutes. The enzyme dissociation was performed according to the manufacturer's protocol.
Mouse brain dissociated with SimpleFlow demonstrated higher preservation of astrocytes and neurons. The enzymatic dissociated brain over-represents microglia, immune cells in the CNS that patrol the brain for damage and pathogens. This is indicative of stress and damage due to the dissociation process.
These findings are consistent with published scientific literature!
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